Timperley Jonathan, Mitchell Andrew R J, Thibault Helene, Mirza Intisar H, Becher Harald
Department of Cardiology, John Radcliffe Hospital, Headington, Oxford, UK.
J Am Soc Echocardiogr. 2005 Feb;18(2):163-7. doi: 10.1016/j.echo.2004.09.003.
Contrast is increasingly being used during dobutamine stress echocardiography. However, there are few data regarding the safety of this combination.
We retrospectively analyzed 751 consecutive stress echocardiograms, 332 without contrast and 419 with contrast (299 with Sonouve, 120 with Optison). Reported side effects and physiologic data were then compared.
There were no fatalities. The incidence of side effects was similar in the 3 groups. The Optison group had a lower diastolic blood pressure compared with the noncontrast group ( P < .05) at rest, and the Sonovue group had a higher peak heart rate compared with the noncontrast group ( P < .001). Patients receiving Optison had more premature atrial contractions ( P < .05) but there was no difference in the incidence of ventricular tachycardia, supraventricular tachycardia, or vagally mediated episodes.
The use of contrast during dobutamine stress echocardiography was not associated with an increased risk of side effects.
在多巴酚丁胺负荷超声心动图检查中，造影剂的使用越来越普遍。然而，关于这种联合使用安全性的数据却很少。
我们回顾性分析了连续751例负荷超声心动图检查，其中332例未使用造影剂，419例使用了造影剂（299例使用声诺维，120例使用欧乃影）。然后比较报告的副作用和生理数据。
无死亡病例。三组副作用发生率相似。静息时，欧乃影组舒张压低于未使用造影剂组（P <.05），声诺维组最高心率高于未使用造影剂组（P <.001）。接受欧乃影的患者房性早搏更多（P <.05），但室性心动过速、室上性心动过速或迷走神经介导事件的发生率无差异。
多巴酚丁胺负荷超声心动图检查中使用造影剂与副作用风险增加无关。
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