血液透析患者的幽门螺杆菌感染：对阿莫西林和克拉霉素的敏感性
Helicobacter pylori infection in hemodialysis patients: susceptibility to amoxicillin and clarithromycin.
作者信息
Aydemir Selim, Boyacioglu Sedat, Gur Gurden, Demirbilek Muge, Can Fusun-Kamber, Korkmaz Murat, Yilmaz Ugur
机构信息
Department of Gastroenterology, Zonguldak Karaelmas University Faculty of Medicine, 67800, Zonguldak, Turkey.
出版信息
World J Gastroenterol. 2005 Feb 14;11(6):842-5. doi: 10.3748/wjg.v11.i6.842.
AIM
To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls.
METHODS
The subjects with dyspeptic complaints were 33 ESRD patients and 46 age- and sex-matched non-uremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched. The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique.
RESULTS
None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of the ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant (P<0.05).
CONCLUSION
Resistance to amoxicillin does not appear to be an important problem in H pylori-infected ESRD and non-uremic patients in our region. In contrast, the rates of resistance to clarithromycin are high, particularly in the ESRD population.
目的
评估终末期肾病（ESRD）患者和非尿毒症对照人群中幽门螺杆菌对阿莫西林和克拉霉素的敏感性。
方法
选取33例有消化不良症状的ESRD患者以及46例年龄和性别匹配、胃窦活检标本显示幽门螺杆菌阳性的非尿毒症对照者。两组在年龄和性别上相匹配。采用琼脂稀释法研究幽门螺杆菌菌株对阿莫西林和克拉霉素的敏感性模式。
结果
两组的幽门螺杆菌菌株经琼脂稀释法检测均未显示对阿莫西林耐药。ESRD组12株（36.4%）菌株和对照组7株（15.2%）菌株对克拉霉素耐药，差异有统计学意义（P<0.05）。
结论
在我们地区，幽门螺杆菌感染的ESRD患者和非尿毒症患者中，对阿莫西林耐药似乎不是一个重要问题。相比之下，对克拉霉素的耐药率较高，尤其是在ESRD人群中。
Zotero 插件