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什么是经典遗传学?

What was classical genetics?

作者信息

Waters C Kenneth

机构信息

Minnesota Center for Philosophy of Science, Department of Philosophy.

出版信息

Stud Hist Philos Sci. 2004 Dec;35(4):783-809. doi: 10.1016/j.shpsa.2004.03.018.

Abstract

I present an account of classical genetics to challenge theory-biased approaches in the philosophy of science. Philosophers typically assume that scientific knowledge is ultimately structured by explanatory reasoning and that research programs in well-established sciences are organized around efforts to fill out a central theory and extend its explanatory range. In the case of classical genetics, philosophers assume that the knowledge was structured by T. H. Morgan's theory of transmission and that research throughout the later 1920s, 30s, and 40s was organized around efforts to further validate, develop, and extend this theory, I show that classical genetics was structured by an integration of explanatory reasoning (associated with the transmission theory) and investigative strategies (such as the 'genetic approach'). The investigative strategies, which have been overlooked in historical and philosophical accounts, were as important as the so-called laws of Mendelian genetics. By the later 1920s, geneticists of the Morgan school were no longer organizing research around the goal of explaining inheritance patterns; rather, they were using genetics to investigate a range of biological phenomena that extended well beyond the explanatory domain of transmission theories. Theory-biased approaches in history and philosophy of science fail to reveal the overall structure of scientific knowledge and obscure the way it functions.

摘要

我阐述经典遗传学,以挑战科学哲学中受理论偏见影响的方法。哲学家通常认为,科学知识最终是由解释性推理构建的,而且成熟科学中的研究项目是围绕充实核心理论并扩展其解释范围的努力而组织起来的。就经典遗传学而言,哲学家们认为,该知识是由托马斯·亨特·摩根的遗传传递理论构建的,并且在整个20世纪20年代后期、30年代和40年代,研究都是围绕进一步验证、发展和扩展这一理论的努力而组织的。我表明,经典遗传学是由解释性推理(与遗传传递理论相关)和研究策略(如“遗传学方法”)的整合构建的。这些研究策略在历史和哲学叙述中被忽视了,它们与孟德尔遗传学的所谓定律同样重要。到20世纪20年代后期,摩根学派的遗传学家不再围绕解释遗传模式的目标来组织研究;相反,他们利用遗传学来研究一系列远远超出遗传传递理论解释范围的生物学现象。科学史和科学哲学中受理论偏见影响的方法未能揭示科学知识的整体结构,也模糊了其运作方式。

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