肝移植受者孕早期使用西罗莫司未出现致畸性。
Absence of teratogenicity of sirolimus used during early pregnancy in a liver transplant recipient.
作者信息
Jankowska I, Oldakowska-Jedynak U, Jabiry-Zieniewicz Z, Cyganek A, Pawlowska J, Teisseyre M, Kalicinski P, Markiewicz M, Paczek L, Socha J
机构信息
Department of Gastroenterology, Hepatology and Immunology, The Children's Memorial Health Institute, Warsaw, Poland.
出版信息
Transplant Proc. 2004 Dec;36(10):3232-3. doi: 10.1016/j.transproceed.2004.11.102.
We describe the case of successful delivery in a 21-year-old woman who became pregnant 3 years after liver transplantation and who received sirolimus during the first 6 weeks of gestation. Sirolimus was discontinued when ultrasonography revealed a pregnancy, she was switched to tacrolimus and prednisone was continued. The course of pregnancy was uneventful; there were no signs or symptoms of graft rejection. Due to fetal intrauterine threatening asphyxia the pregnancy was concluded by cesarean section in the 39th gestational week, delivering a healthy, 2950 g, Apgar 10, female infant.
我们描述了一名21岁女性成功分娩的病例。该女性在肝移植3年后怀孕，并在妊娠的前6周接受了西罗莫司治疗。超声检查发现怀孕后停用了西罗莫司，转而使用他克莫司，并继续使用泼尼松。妊娠过程顺利，没有移植物排斥的迹象或症状。由于胎儿宫内窘迫，妊娠在第39孕周通过剖宫产结束，产下一名健康的女婴，体重2950克，阿氏评分10分。
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