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Promoter-dependent roles for the Srb10 cyclin-dependent kinase and the Hda1 deacetylase in Tup1-mediated repression in Saccharomyces cerevisiae.
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Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid.
Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3370-5. doi: 10.1073/pnas.0400221101. Epub 2004 Feb 26.
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Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex.
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Recruitment of Tup1-Ssn6 by yeast hypoxic genes and chromatin-independent exclusion of TATA binding protein.
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A distal, high-affinity binding site on the cyclin-CDK substrate Pho4 is important for its phosphorylation and regulation.
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Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12.
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