肾素-血管紧张素系统：除血管紧张素II之外的肽类和酶类
The renin-angiotensin system: peptides and enzymes beyond angiotensin II.
作者信息
Reudelhuber Timothy L
机构信息
Laboratory of Molecular Biochemistry of Hypertension, Clinical Research Institute of Montreal (IRCM), 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada.
出版信息
Curr Opin Nephrol Hypertens. 2005 Mar;14(2):155-9. doi: 10.1097/00041552-200503000-00011.
PURPOSE OF REVIEW
Although current pharmacotherapy for cardiovascular disease focuses on the inhibition of angiotensin II production and action, several other biologically active peptides are produced by the renin-angiotensin system.
RECENT FINDINGS
Recent biochemical and physiological studies have shown that non-angiotensin II peptides, including angiotensins III, IV and 1-7, modulate blood pressure or cardiac function through novel mechanisms. Animal models support the notion that these peptides are physiologically important.
SUMMARY
Although the role of these peptides has not yet resulted in the development of new therapies for the treatment of cardiovascular disease, they hold promise for identification of complimentary targets.
综述目的
尽管目前用于心血管疾病的药物治疗主要集中在抑制血管紧张素II的产生和作用，但肾素-血管紧张素系统还会产生其他几种生物活性肽。
最新发现
最近的生化和生理学研究表明，包括血管紧张素III、IV和1-7在内的非血管紧张素II肽，通过新的机制调节血压或心脏功能。动物模型支持这些肽具有重要生理作用的观点。
总结
尽管这些肽的作用尚未促成心血管疾病新疗法的开发，但它们有望成为补充性治疗靶点。
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