人类冠状病毒发病机制中的肾素-血管紧张素系统。
Renin-angiotensin system in human coronavirus pathogenesis.
作者信息
Wevers Brigitte A, van der Hoek Lia
机构信息
Center for Experimental & Molecular Medicine, Center for Infection & Immunity Amsterdam, Academic Medical Center, University of Amsterdam, PO Box 226600, 1100 DD Amsterdam, The Netherlands.
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection & Immunity Amsterdam, Academic Medical Center, University of Amsterdam, PO Box 226600, 1100 DD Amsterdam, The Netherlands. Tel.: +31 205 667 510; ;
出版信息
Future Virol. 2010 Mar;5(2):145-161. doi: 10.2217/fvl.10.4. Epub 2010 Mar 1.
Although initially considered relatively harmless pathogens, human coronaviruses (HCoVs) are nowadays known to be associated with more severe clinical complications. Still, their precise pathogenic potential is largely unknown, particularly regarding the most recently identified species HCoV-NL63 and HCoV-HKU1. HCoVs need host cell proteins to successively establish infections. Proteases of the renin-angiotensin system serve as receptors needed for entry into target cells; this article describes the current knowledge on the involvement of this system in HCoV pathogenesis.
虽然人类冠状病毒（HCoVs）最初被认为是相对无害的病原体，但如今已知它们与更严重的临床并发症有关。然而，它们的确切致病潜力在很大程度上仍然未知，尤其是对于最近发现的HCoV-NL63和HCoV-HKU1这两个病毒种类。HCoVs需要宿主细胞蛋白来相继建立感染。肾素-血管紧张素系统的蛋白酶作为进入靶细胞所需的受体；本文描述了关于该系统参与HCoV发病机制的当前知识。
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