泛素连接酶Cullin-RING的功能与调控

Function and regulation of cullin-RING ubiquitin ligases.

作者信息

Petroski Matthew D, Deshaies Raymond J

机构信息

Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA.

出版信息

Nat Rev Mol Cell Biol. 2005 Jan;6(1):9-20. doi: 10.1038/nrm1547.

DOI:10.1038/nrm1547

PMID:15688063

Abstract

Cullin-RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin-RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin-RING ligases, and describe how these enzymes can be characterized by a set of general principles.

摘要

泛素连接酶复合物是已知最大的一类泛素连接酶。由于其底物受体亚基的多样性，真核细胞中可能存在数百种不同的泛素连接酶复合物，这使这些酶成为翻译后蛋白质调控的关键介质。在本综述中，我们重点关注泛素连接酶复合物的组成、调控和功能，并描述如何通过一组通用原则来表征这些酶。