植物发育和环境响应中的 CUL3 E3 连接酶。
CUL3 E3 ligases in plant development and environmental response.
机构信息
Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
出版信息
Nat Plants. 2021 Jan;7(1):6-16. doi: 10.1038/s41477-020-00833-6. Epub 2021 Jan 15.
Abstract
Thirty years of research have revealed the fundamental role of the ubiquitin-proteasome system in diverse aspects of cellular regulation in eukaryotes. The ubiquitin-protein ligases or E3s are central to the ubiquitin-proteasome system since they determine the specificity of ubiquitylation. The cullin-RING ligases (CRLs) constitute one large class of E3s that can be subdivided based on the cullin isoform and the substrate adapter. SCF complexes, composed of CUL1 and the SKP1/F-box protein substrate adapter, are perhaps the best characterized in plants. More recently, accumulating evidence has demonstrated the essential roles of CRL3 E3s, consisting of a CUL3 protein and a BTB/POZ substrate adaptor. In this Review, we describe the variety of CRL3s functioning in plants and the wide range of processes that they regulate. Furthermore, we illustrate how different classes of E3s may cooperate to regulate specific pathways or processes.
摘要
三十年来的研究揭示了泛素-蛋白酶体系统在真核生物细胞调节的多个方面的基本作用。泛素蛋白连接酶或 E3 是泛素-蛋白酶体系统的核心，因为它们决定了泛素化的特异性。Cullin-RING 连接酶（CRLs）构成了 E3 的一大类，可以根据 Cullin 同工型和底物衔接子进行细分。由 CUL1 和 SKP1/F-box 蛋白底物衔接子组成的 SCF 复合物在植物中可能是研究得最透彻的。最近，越来越多的证据表明，由 CUL3 蛋白和 BTB/POZ 底物衔接子组成的 CRL3 E3 在植物中发挥着重要作用。在这篇综述中，我们描述了在植物中发挥作用的多种 CRL3 及其调节的广泛过程。此外，我们还说明了不同类别的 E3 如何合作来调节特定的途径或过程。
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