Schindler C, Paessler L, Eckelt U, Kirch W
Institute of Clinical Pharmacology, Medical Faculty, University of Technology, Dresden, Germany.
J Oral Pathol Med. 2005 Mar;34(3):184-6. doi: 10.1111/j.1600-0714.2004.00247.x.
Steroid injections into joints are frequently used to control symptomatic pain. Risks associated with intra-articular steroid injections are not well documented.
We report the case of a 29-year-old woman who was referred to a dental surgeon because of a suspected relationship between persisting chronic back pain and an arthrosis of the temporomandibular joint (TMJ).
The dental surgeon diagnosed capsulitis of the right TMJ and injected 40 mg triamcinolone into the joint. Within 4 months the patient developed progressive pain and trismus of the right TMJ and the intra-articular injection was repeated. An occlusal splint slightly improved the patients' symptoms but induced crepitus. Magnetic resonance imaging revealed a disk dislocation in the right TMJ and severe necrosis of the condyle. The patient had persisting pain and ankylosis. Surgical restoration of the TMJ revealed a bony apposition in the fossa deformed with the socket of the joint, extensive medial erosion of the condyle and complete destruction of the disk.
This case report supports earlier observations that intra-articular glucocorticoid injections, if used in a wrong way, may cause severe destruction of a joint.
向关节内注射类固醇常用于控制症状性疼痛。关节内注射类固醇相关的风险尚无充分记录。
我们报告了一名29岁女性的病例,该患者因持续性慢性背痛与颞下颌关节(TMJ)关节炎之间的疑似关联而被转诊至牙科医生处。
牙科医生诊断为右侧TMJ囊炎,并向关节内注射了40毫克曲安奈德。在4个月内,患者右侧TMJ出现进行性疼痛和牙关紧闭,于是再次进行关节内注射。咬合夹板使患者症状稍有改善,但引发了摩擦音。磁共振成像显示右侧TMJ盘状移位和髁突严重坏死。患者持续疼痛并出现关节强直。TMJ的手术修复显示关节窝内有骨赘形成,关节窝变形,髁突广泛内侧侵蚀,盘状结构完全破坏。
本病例报告支持了早期的观察结果,即关节内注射糖皮质激素如果使用不当,可能会导致关节严重破坏。