骨佩吉特病
Paget disease of bone.
作者信息
Roodman G David, Windle Jolene J
机构信息
Department of Medicine, Division of Hematology-Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15240, USA.
出版信息
J Clin Invest. 2005 Feb;115(2):200-8. doi: 10.1172/JCI24281.
Abstract
Paget disease of bone (PD) is characterized by excessive bone resorption in focal areas followed by abundant new bone formation, with eventual replacement of the normal bone marrow by vascular and fibrous tissue. The etiology of PD is not well understood, but one PD-linked gene and several other susceptibility loci have been identified, and paramyxoviral gene products have been detected in pagetic osteoclasts. In this review, the pathophysiology of PD and evidence for both a genetic and a viral etiology for PD will be discussed.
摘要
骨佩吉特病（PD）的特征是局部区域骨吸收过度，随后有大量新骨形成，最终正常骨髓被血管和纤维组织替代。PD的病因尚不完全清楚，但已鉴定出一个与PD相关的基因和其他几个易感基因座，并且在佩吉特破骨细胞中检测到副粘病毒基因产物。在本综述中，将讨论PD的病理生理学以及PD的遗传病因和病毒病因的证据。
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