成骨细胞与骨 Paget 病。
Osteocytes and Paget's Disease of Bone.
机构信息
Division of Hematology and Oncology, Department of Medicine, Indiana University, Indianapolis, IN, USA.
Department of Physiology and Cell Biology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
出版信息
Curr Osteoporos Rep. 2024 Apr;22(2):266-272. doi: 10.1007/s11914-024-00863-5. Epub 2024 Mar 8.
PURPOSE OF REVIEW
To describe the contributions of osteocytes to the lesions in Paget's disease, which are characterized by locally overactive bone resorption and formation.
RECENT FINDINGS
Osteocytes, the most abundant cells in bone, are altered in Paget's disease lesions, displaying increased size, decreased canalicular length, incomplete differentiation, and less sclerostin expression compared to controls in both patients and mouse models. Pagetic lesions show increased senescent osteocytes that express RANK ligand, which drives osteoclastic bone resorption. Abnormal osteoclasts in Paget's disease secrete abundant IGF1, which enhances osteocyte senescence, contributing to lesion formation. Recent data suggest that osteocytes contribute to lesion formation in Paget's disease by responding to high local IGF1 released from abnormal osteoclasts. Here we describe the characteristics of osteocytes in Paget's disease and their role in bone lesion formation based on recent results with mouse models and supported by patient data.
目的综述
描述破骨细胞在 Pagetic 疾病病变中的作用，Pagetic 疾病的特征为局部骨吸收和形成过度活跃。
最新发现
与对照相比，Pagetic 疾病病变中的成骨细胞（骨中最丰富的细胞）发生改变，表现为体积增大、细胞内管腔长度减少、分化不完全以及骨硬化蛋白表达减少。与对照相比，患者和小鼠模型 Pagetic 病变中的破骨细胞表达更多的核因子-κB 受体激活因子配体（RANKL），这会驱动破骨细胞的骨吸收。Pagetic 疾病中的异常破骨细胞会分泌大量的胰岛素样生长因子 1（IGF1），这会增强成骨细胞衰老，从而导致病变形成。最近的数据表明，成骨细胞通过响应异常破骨细胞释放的高局部 IGF1 来参与 Pagetic 疾病的病变形成。在此，我们根据最新的小鼠模型结果并结合患者数据，描述 Pagetic 疾病中成骨细胞的特征及其在骨病变形成中的作用。
Zotero 插件