Phan T C A, Xu J, Zheng M H
Department of Orthopaedic Surgery, University of Western Australia, Nedlands, Australia.
Histol Histopathol. 2004 Oct;19(4):1325-44. doi: 10.14670/HH-19.1325.
The intercellular communication between osteoblasts and osteoclasts is crucial to bone homeostasis. Since Rodan and Martin proposed the control of osteoclasts by osteoblasts in the 1980s, many factors have been isolated from osteoblasts and shown to regulate the differentiation and function of osteoclasts. However, the mechanism by which osteoblasts regulate osteoclasts during bone remodelling is still unclear. On the other hand, it is well accepted that many metabolic bone diseases are associated with the disruption of the communication between osteoblast and osteoclasts. Thus, this review focuses on the cross-talk between osteoblasts and osteoclasts and its impact in bone disease.
成骨细胞与破骨细胞之间的细胞间通讯对骨稳态至关重要。自20世纪80年代罗丹和马丁提出成骨细胞对破骨细胞的控制以来，许多因子已从成骨细胞中分离出来，并被证明可调节破骨细胞的分化和功能。然而，在骨重塑过程中，成骨细胞调节破骨细胞的机制仍不清楚。另一方面，人们普遍认为许多代谢性骨疾病与成骨细胞和破骨细胞之间通讯的破坏有关。因此，本综述重点关注成骨细胞与破骨细胞之间的相互作用及其对骨疾病的影响。
