Kutlar Irfan, Aksoy Fuat, Koyluoglu Oya, Ugur Mete Gurol, Balat Ozcan, Tarakcioglu Mehmet
Department of Obstetrics and Gynecology, Sahinbey Medical Center, Gaziantep University, Milli Egemenlik Bulvari 32/6, 27060, Gaziantep, Turkey.
Arch Gynecol Obstet. 2005 Jul;272(2):124-6. doi: 10.1007/s00404-004-0694-y. Epub 2005 Feb 3.
The aim of this study is to assess adenosine deaminase (ADA) activity in the serum and placenta of patients with missed abortions, anembryonic pregnancies, and voluntary abortions.
Nine cases of anembryonic pregnancies and 21 cases of missed abortions (group I, n=30), and voluntary dilatation and curettage cases (group II, n=30) were included in this prospective study. Adenosine deaminase activity in serum and placental tissue was measured according to the Giusti method. The t-test was applied for statistical evaluation with the help of SPSS 9.0.
The mean serum ADA level in the abortion cases (group I) was 9.13+/-1.59 U/l, while it was 17.06+/-6.5 U/l in the control group (group II; p<0.05). Also, the mean placental ADA levels in abortion cases and in the control group were 11.8+/-4.7 nmol/mg protein/min and 25.8+/-6.6 nmol/mg protein/min respectively (p<0.05).
These results suggest that ADA may have a modulatory role in the implantation and duration of pregnancy. Low levels of ADA in early pregnancy may lead to an accumulation of products toxic to DNA and to the subsequent loss of the pregnancy.
本研究旨在评估稽留流产、胚胎停育及人工流产患者血清及胎盘组织中腺苷脱氨酶（ADA）的活性。
本前瞻性研究纳入9例胚胎停育患者、21例稽留流产患者（第一组，n = 30）及人工流产刮宫患者（第二组，n = 30）。采用Giusti法测定血清及胎盘组织中腺苷脱氨酶活性。借助SPSS 9.0软件应用t检验进行统计学评估。
流产组（第一组）血清ADA平均水平为9.13±1.59 U/l，而对照组（第二组）为17.06±6.5 U/l（p<0.05）。此外，流产组与对照组胎盘ADA平均水平分别为11.8±4.7 nmol/mg蛋白/分钟和25.8±6.6 nmol/mg蛋白/分钟（p<0.05）。
这些结果提示ADA可能在妊娠着床及持续时间方面具有调节作用。妊娠早期ADA水平较低可能导致对DNA有毒性的产物蓄积，进而导致妊娠丢失。
