Bukulmez G, Akan T, Ciliv G
University Faculty of Medicine, Department of Dermatology, Ankara, Turkey 06100, USA.
Eur J Dermatol. 2000 Jun;10(4):274-6.
Adenosine deaminase (ADA) activity is a nonspecific marker of T cell activation. T cell activation is thought to play an important role in the pathogenesis of psoriasis. Our purpose was to assess the significance of serum ADA activity in psoriasis and its relevance to disease activity. ADA activity was determined with an enzymatic method in 25 patients with psoriasis and in 15 healthy subjects. These measurements were repeated for 10 patients after either PUVA or cyclosporin A treatments. Disease activity was estimated by the PASI scoring system. Serum ADA level was significantly elevated in patients with psoriasis compared to healthy subjects (p<0.05). There was a significant decrease in the ADA levels after treatment compared to pretreatment values in the same patients (p<0.05). There was no correlation between ADA levels and PASI scores. These results support the evidence that T cell activation is involved in the pathogenesis of psoriasis and that ADA may be valuable in the assessment of disease activity in psoriasis.
腺苷脱氨酶（ADA）活性是T细胞活化的非特异性标志物。T细胞活化被认为在银屑病的发病机制中起重要作用。我们的目的是评估血清ADA活性在银屑病中的意义及其与疾病活动度的相关性。采用酶法测定了25例银屑病患者和15名健康受试者的ADA活性。对其中10例患者在接受补骨脂素加紫外线A（PUVA）或环孢素A治疗后重复进行了这些测量。通过银屑病面积和严重程度指数（PASI）评分系统评估疾病活动度。与健康受试者相比，银屑病患者的血清ADA水平显著升高（p<0.05）。与同一患者治疗前的值相比，治疗后ADA水平显著降低（p<0.05）。ADA水平与PASI评分之间无相关性。这些结果支持了T细胞活化参与银屑病发病机制以及ADA可能在评估银屑病疾病活动度方面具有价值的证据。
