Chng Seo Yi, Van Bever Hugo P, Lian Derrick, Lee Shan Xian, Xu Xin Ni, Wang Xiao Shan, Goh Daniel Yam Thiam
Paediatric Pulmonary, Sleep and Critical Care Service, The Children's Medical Institute, Department of Paediatrics, National University Hospital, Singapore.
Respirology. 2005 Jan;10(1):40-5. doi: 10.1111/j.1440-1843.2005.00628.x.
The relationship between exhaled nitric oxide and atopy is controversial. The aim of this study was to determine the relationship between exhaled nitric oxide (FE(NO)) and atopy in Asian young adults.
Subjects were assessed by: (i) the International Study of Asthma and Allergies in Childhood questionnaire to differentiate asthmatic from nonasthmatic and rhinitis from non-rhinitis subjects; (ii) skin prick testing to 10 allergens; and (iii) FE(NO) measurements performed online at a flow rate of 50 mL/s.
Complete results were available for 84 subjects. FE(NO) values were highest in atopic asthmatics (n = 34; median FE(NO), 59.8 p.p.b.; interquartile range, 30.4-85.5 p.p.b), followed by atopic nonasthmatics (n = 34; median, 38.4 p.p.b.; range, 16.7-49.3 p.p.b), nonatopic asthmatics (n = 5; median, 19.1 p.p.b.; range, 17.9-33.4 p.p.b), and lowest in nonatopic nonasthmatics (n = 11; median, 15.7 p.p.b.; range, 11.5-21.7 p.p.b). FE(NO) values were significantly higher in atopic (n = 68; median, 44.7 p.p.b.; range, 27.3-75.2 p.p.b) compared to nonatopic subjects (n = 16; median, 17.0 p.p.b.; range, 11.7-23.8 p.p.b.; P < 0.0001), regardless of asthma and rhinitis status. FE(NO) levels correlated with the severity of atopy (wheal size) for both asthmatic (r = 0.44, P = 0.005) and nonasthmatic subjects (r = 0.48, P = 0.001). There was no significant difference in FE(NO) levels between nonatopic asthmatics and nonatopic nonasthmatic subjects (P = 0.25).
Increased FE(NO) levels are more reflective of atopy rather than asthma, and increased nitric oxide production may be predominantly a feature of atopy in asthmatics.
呼出一氧化氮与特应性之间的关系存在争议。本研究的目的是确定亚洲年轻成年人中呼出一氧化氮（FE(NO)）与特应性之间的关系。
通过以下方式对受试者进行评估：（i）儿童哮喘和过敏国际研究问卷，以区分哮喘患者与非哮喘患者以及鼻炎患者与非鼻炎患者；（ii）对10种变应原进行皮肤点刺试验；（iii）以50 mL/s的流速在线测量FE(NO)。
84名受试者有完整结果。FE(NO)值在特应性哮喘患者中最高（n = 34；FE(NO)中位数为59.8 ppb；四分位间距为30.4 - 85.5 ppb），其次是特应性非哮喘患者（n = 34；中位数为38.4 ppb；范围为16.7 - 49.3 ppb）、非特应性哮喘患者（n = 5；中位数为19.1 ppb；范围为17.9 - 33.4 ppb），在非特应性非哮喘患者中最低（n = 11；中位数为15.7 ppb；范围为11.5 - 21.7 ppb）。无论哮喘和鼻炎状态如何，特应性受试者（n = 68；中位数为44.7 ppb；范围为27.3 - 75.2 ppb）的FE(NO)值显著高于非特应性受试者（n = 16；中位数为17.0 ppb；范围为11.7 - 23.8 ppb；P < 0.0001）。FE(NO)水平与哮喘患者（r = 0.44，P = 0.005）和非哮喘患者（r = 0.48，P = 0.001）的特应性严重程度（风团大小）相关。非特应性哮喘患者和非特应性非哮喘患者之间的FE(NO)水平无显著差异（P = 0.25）。
FE(NO)水平升高更反映特应性而非哮喘，一氧化氮产生增加可能主要是哮喘患者特应性的一个特征。
