死后大脑中精神分裂症、双相情感障碍和重度抑郁症的神经化学标志物。

Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains.

作者信息

Torrey E Fuller, Barci Beata M, Webster Maree J, Bartko John J, Meador-Woodruff James H, Knable Michael B

机构信息

Stanley Medical Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

出版信息

Biol Psychiatry. 2005 Feb 1;57(3):252-60. doi: 10.1016/j.biopsych.2004.10.019.

DOI:10.1016/j.biopsych.2004.10.019

PMID:15691526

Abstract

BACKGROUND

Previous studies of postmortem neurochemical markers in severe psychiatric disorders have been carried out on different brain collections, making it difficult to compare results.

METHODS

One hundred RNA, protein, and other neurochemical markers were assessed in a single set of 60 postmortem brains (15 each with schizophrenia, bipolar disorder, major depression without psychosis, and unaffected control subjects) in relation to seven neurochemical systems. Quantitative measures of continuous variables for prefrontal, hippocampus, anterior cingulate, superior temporal cortex, or a combination of these were analyzed from published and unpublished studies by 56 research groups.

RESULTS

Before correcting for multiple comparisons, 23% of markers (23/100) were abnormal in one or more regions, with most indicating decreased expression. The largest percentage were associated with the developmental/synaptic (10/22) and gamma-aminobutyric acid (GABA; 3/7) systems. Bipolar disorder (20) and schizophrenia (19) had the most abnormalities, with a 65% overlap. When all brain areas were considered together and corrected for multiple comparisons, reelin, parvalbumin, and GAD67 were the most abnormal.

CONCLUSIONS

Confirming other studies, the GABA and developmental/synaptic neurochemical systems are promising areas for research on schizophrenia and bipolar disorder. Research should include tissue from both diseases, and additional brain areas should be assessed.

摘要

背景

以往关于严重精神疾病死后神经化学标志物的研究是在不同的脑标本上进行的，这使得结果难以比较。

方法

在一组60个死后大脑（精神分裂症、双相情感障碍、无精神病性症状的重度抑郁症各15例，未受影响的对照受试者15例）中，针对七个神经化学系统评估了100种RNA、蛋白质和其他神经化学标志物。56个研究小组对已发表和未发表研究中的前额叶、海马体、前扣带回、颞上叶皮质或这些区域组合的连续变量进行了定量测量分析。

结果

在进行多重比较校正之前，23%的标志物（23/100）在一个或多个区域异常，大多数显示表达降低。最大比例与发育/突触（10/22）和γ-氨基丁酸（GABA；3/7）系统相关。双相情感障碍（20个）和精神分裂症（19个）的异常最多，重叠率为65%。当将所有脑区综合考虑并进行多重比较校正后，Reelin、小白蛋白和GAD67异常最为明显。