Salehirad Mahsa, Mobinhosseini Fatemehsadat, Hayes A Wallace, Hekmati Malak, Motaghinejad Majid, Yousefi Mohammad
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Tehran, Iran.
University of South Florida College of Public Health, Tampa, FL, USA.
Adv Biomed Res. 2025 Jul 21;14:57. doi: 10.4103/abr.abr_253_23. eCollection 2025.
Bipolar disorder (BD), or bipolar disease, is a prevalent psychiatric condition. Current treatment options are often ineffective, with numerous side effects. Brain-derived neurotrophic factor (BDNF) may be a potential biomarker for BD.
Synthesized curcumin-conjugated ZnO nanoparticles (Cur-ZnO NPs) and curcumin-conjugated MgO nanoparticles (Cur-MgO NPs) were characterized by Fourier transform infrared, field emission scanning electron microscopy, (energy dispersive X-ray analysis (EDX), and ultraviolet-visible spectrophotometry. Behavioral changes in an open field test and the level of hippocampal BDNF were evaluated in a ketamine-induced manic-depressive-like behavior mouse model. Mice were treated intraperitoneal daily for 14 days. Control mice received saline; positive control mice received 25 mg/kg ketamine. Lithium (45 mg/kg), 5 mg/kg magnesium oxide (MgO), 5 mg/kg zinc oxide (ZnO), or 40 mg/kg curcumin was administrated in separates groups simultaneously with ketamine (25 mg/kg). Mice in the treatment group were given ketamine (25 mg/kg) plus Cur-MgO NPs or Cur-ZnO NPs (10, 20, or 40 mg/kg).
Both nanoparticles were chemically characterized. Both nanoparticles increased central square entries, time spent in the center zone, the rearing frequency, and ambulation distance in the ketamine-treated mice in the OFT. The hippocampal BDNF levels were also increased compared to the ketamine-treated mice.
Cur-ZnO NPs and Cur-MgO NPs may be potential candidates for treating manic-depressive-like disorders.
双相情感障碍（BD），又称双相疾病，是一种常见的精神疾病。目前的治疗方案往往效果不佳，且有诸多副作用。脑源性神经营养因子（BDNF）可能是双相情感障碍的一种潜在生物标志物。
通过傅里叶变换红外光谱、场发射扫描电子显微镜、能量色散X射线分析（EDX）和紫外可见分光光度法对合成的姜黄素共轭氧化锌纳米颗粒（Cur-ZnO NPs）和姜黄素共轭氧化镁纳米颗粒（Cur-MgO NPs）进行表征。在氯胺酮诱导的躁狂-抑郁样行为小鼠模型中评估旷场试验中的行为变化以及海马BDNF水平。小鼠每天腹腔注射给药，持续14天。对照小鼠接受生理盐水；阳性对照小鼠接受25 mg/kg氯胺酮。锂（45 mg/kg）、5 mg/kg氧化镁（MgO）、5 mg/kg氧化锌（ZnO）或40 mg/kg姜黄素分别与氯胺酮（25 mg/kg）同时给予不同组的小鼠。治疗组小鼠给予氯胺酮（25 mg/kg）加Cur-MgO NPs或Cur-ZnO NPs（10、20或40 mg/kg）。
对两种纳米颗粒进行了化学表征。两种纳米颗粒均增加了氯胺酮处理小鼠在旷场试验中的中央格进入次数、在中央区域停留的时间、竖毛频率和行走距离。与氯胺酮处理的小鼠相比，海马BDNF水平也有所升高。
Cur-ZnO NPs和Cur-MgO NPs可能是治疗躁狂-抑郁样疾病的潜在候选药物。
