Schönberger H J, Dompeling E, Knottnerus J A, Kuiper S, van Weel C, Schayck C P
Department of General Practice, University Hospital Maastricht, Research Institute CAPHRI, The Netherlands.
Pediatr Allergy Immunol. 2005 Feb;16(1):27-31. doi: 10.1111/j.1399-3038.2005.00243.x.
To examine the relationship between prenatal exposure to mite, cat and dog allergens and total serum IgE at birth in newborns at high risk of asthma. In the homes of 221 newborns with at least one first-degree relative with asthma, concentrations (ng/g dust) of allergens of house dust mite (mite), cat and dog were measured at the fourth to sixth month of pregnancy in dust samples from the maternal mattress and living room. At day 3-5 after birth, total IgE was measured in capillary heel blood. A total number of 174 blood samples were available (11 mothers refused newborn's blood sampling, and in 36 cases the blood sample was too small for analysis). In 24% of the newborns, total IgE was elevated (cut-off value 0.5 IU/ml). A significant dose response relationship was found between increasing mite allergen levels [divided in quartiles ng/g dust (qrt)] and the percentage of elevated IgE: first qrt (0-85 ng/g) 13%; second qrt (86-381) 19%; third qrt (382-2371) 26%; fourth qrt (> or =2372) 42%, respectively, p=0.01. This relationship remained significant after adjusting for passive smoking, maternal and paternal mite allergy, socio-demographic factors, birth characteristics and (breast) feeding practice in the first week of life. In high-risk newborns, prenatal exposure to mite allergens, but not to cat and dog allergens from dust of the living room and of the maternal mattress was associated with total serum IgE at birth.
探讨哮喘高危新生儿出生时,产前暴露于螨、猫和狗过敏原与血清总IgE之间的关系。在221名至少有一位一级亲属患有哮喘的新生儿家庭中,于孕期第四至六个月,采集母亲床垫和客厅灰尘样本,测量屋尘螨(螨)、猫和狗过敏原的浓度(ng/g灰尘)。出生后第3 - 5天,采集足跟毛细血管血测量总IgE。共获得174份血样(11位母亲拒绝采集新生儿血样,36例血样量过少无法分析)。24%的新生儿总IgE升高(临界值0.5 IU/ml)。发现螨过敏原水平升高[分为四分位数ng/g灰尘(qrt)]与IgE升高百分比之间存在显著的剂量反应关系:第一四分位数(0 - 85 ng/g)为13%;第二四分位数(86 - 381)为19%;第三四分位数(382 - 2371)为26%;第四四分位数(≥2372)为42%,p = 0.01。在对被动吸烟、父母螨过敏、社会人口统计学因素、出生特征以及出生后第一周的(母乳)喂养方式进行校正后,这种关系仍然显著。在高危新生儿中,产前暴露于螨过敏原,但不包括客厅和母亲床垫灰尘中的猫和狗过敏原,与出生时的血清总IgE相关。