Li J S, Hassouna M, Sawan M, Duval F, Latt R, Carter K, Collier B, Elhilali M M
Urology Research Laboratory, Royal Victorial Hospital, McGill University, Montreal, Quebec, Canada.
J Urol. 1992 May;147(5):1429-34. doi: 10.1016/s0022-5347(17)37587-0.
Neural stimulation is potentially a valuable therapeutic tool in the treatment of neurogenic bladder with detrusor areflexia. We studied 20 dogs in different groups, up to eight months, and compared the effect of electric stimulation with intermittent catheterization, specially during spinal shock phase. We found that early stimulation hastened the return of detrusor activity. When stimulation was delayed, the bladder could still regain its activity, and when the pace-maker was turned off, the detrusor activity was gradually decreased. Neurostimulation can completely empty bladder up to eight months. The lowest A.Ch. content in detrusor muscle was found in intermittent catheterization group and in this group the detrusor strips showed marked supersensitivity to urecholine stimulation than the bladders managed by electric stimulation. Also, we found that electric stimulation reduced the complications caused by intermittent catheterization and protected kidney function.
神经刺激在治疗逼尿肌无反射的神经源性膀胱方面可能是一种有价值的治疗工具。我们对不同组的20只狗进行了长达八个月的研究,并比较了电刺激与间歇性导尿的效果,特别是在脊髓休克阶段。我们发现早期刺激加速了逼尿肌活动的恢复。当刺激延迟时,膀胱仍可恢复其活动,而当起搏器关闭时,逼尿肌活动逐渐减少。神经刺激在长达八个月的时间里可使膀胱完全排空。在间歇性导尿组中发现逼尿肌中乙酰胆碱含量最低,且该组逼尿肌条对乌拉胆碱刺激的超敏反应比接受电刺激处理的膀胱更明显。此外,我们发现电刺激减少了间歇性导尿引起的并发症并保护了肾功能。