Groen J, Van Asselt E, Van Mastrigt R, Bosch R, Van Koeveringe G A
Department of Urology, Erasmus University, Rotterdam, The Netherlands.
J Urol. 1993 Sep;150(3):1002-6. doi: 10.1016/s0022-5347(17)35674-4.
To study the relative importance of neurogenic factors in detrusor contractility, active bladder wall stress values were compared in situ and in vitro. Eight male guinea pigs were used. The active stress in the bladder wall in spontaneous micturition contractions was calculated from the results of urodynamic examinations and compared with the active stress developed in response to optimum electrical stimulation in full-thickness bladder wall strips taken from the same bladders. The results indicated that, in normal micturition, the detrusor muscle is not fully stimulated, and the rate of pressure development is not determined by mechanical factors. To identify topological variations of detrusor contractility, the strips were taken from three different locations. It was found that strips from the posterior wall contracted more forcefully than those from the anterior wall.
为研究神经源性因素在逼尿肌收缩性中的相对重要性，对原位和体外的膀胱壁主动应力值进行了比较。使用了8只雄性豚鼠。根据尿动力学检查结果计算自发性排尿收缩时膀胱壁的主动应力，并与取自同一膀胱的全层膀胱壁条带在最佳电刺激下产生的主动应力进行比较。结果表明，在正常排尿时，逼尿肌未得到充分刺激，压力上升速率不由机械因素决定。为确定逼尿肌收缩性的拓扑变化，从三个不同位置取材制作条带。发现后壁取材的条带比前壁取材的条带收缩更有力。
