Wang Chun-Xia, Hou Lian-Bing, Ma Yun
Department of Pharmaceutics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2005 Feb;25(2):187-9, 200.
To observe the effect Changtong oral liquid (CTOL), a traditional Chinese drug preparation, on the prevention of postoperative intestinal adhesion.
Fifty-four male SD rats were randomly divided into 6 equal groups, namely the normal control, model control, Simo decoction (SMD, another traditional Chinese drug preparation), and CTOL groups, and CTOL group included three subgroups treated at low, moderate and high doses. Except for those in the normal control group, all the other rats were subjected to operation with Ellis' method for establishing intestinal adhesion models. After the operation, the rats in the normal control and model groups received intragastric administration of distilled water (10 ml/kg), SMD group received SMD administration in similar manner at the dose of 10 ml/kg, and the three CTOL groups had CTOL at the doses of 4.3, 8.6 and 17.2 g/kg, respectively. On day 7 after surgery, blood sample were taken from all the rats to determine the white blood cell (WBC) count and fibrinogen (FIB) concentrations, and the intestinal adhesion was graded.
CTOL evidently reduced the severity of postoperative adhesion and decreased WBC count and plasma FIB level, suggesting the efficacy of CTOL in inhibiting the formation of postoperative intestinal adhesion.
观察中药制剂肠通口服液（CTOL）预防术后肠粘连的效果。
将54只雄性SD大鼠随机分为6组，每组9只，即正常对照组、模型对照组、四磨汤（SMD，另一种中药制剂）组和CTOL组，CTOL组又分为低、中、高剂量三个亚组。除正常对照组外，其余大鼠均采用埃利斯法手术建立肠粘连模型。术后，正常对照组和模型组大鼠灌胃给予蒸馏水（10 ml/kg），SMD组大鼠按10 ml/kg剂量灌胃给予四磨汤，CTOL组三个亚组大鼠分别按4.3、8.6和17.2 g/kg剂量灌胃给予肠通口服液。术后第7天，采集所有大鼠的血液样本，检测白细胞（WBC）计数和纤维蛋白原（FIB）浓度，并对肠粘连进行分级。
肠通口服液明显减轻了术后粘连的严重程度，降低了白细胞计数和血浆纤维蛋白原水平，提示肠通口服液对抑制术后肠粘连的形成有效。
