Hancock R L
Canadian Institute of Theoretical Biology, Scott's Bay, Nova Scotia.
Med Hypotheses. 1992 Jan;37(1):12-5. doi: 10.1016/0306-9877(92)90004-v.
This is the final section of an intermediate phase of generalizations dealing with aspects of enhancers. It is concluded that a binding type protein(s) complex near a LTR segment. This creates destabilization of heterochromatin that allows transcription mechanisms. If this process is promoted by anomalous enhancer activity such as those produced by chemical inducers which modify chromatin states or cause hypomethylated enhancer regions, then normally repressed embryonic gene products, such as protooncogene growth factors, can be transcribed inappropriately to a specific developmental stage, eg post-embryonically.
这是关于增强子各方面内容的中间阶段概括的最后一部分。得出的结论是，在长末端重复序列（LTR）片段附近存在一种结合型蛋白质复合物。这会导致异染色质不稳定，从而使转录机制得以进行。如果这个过程是由异常的增强子活性所促进的，比如由改变染色质状态或导致增强子区域低甲基化的化学诱导剂所产生的异常增强子活性，那么通常被抑制的胚胎基因产物，如原癌基因生长因子，可能会在特定发育阶段被不恰当地转录，例如在胚胎后期。
