Hancock R L
Med Hypotheses. 1986 Apr;19(4):403-12. doi: 10.1016/0306-9877(86)90116-7.
The term embryonic gene is discussed in which an operational definition is given, namely that it be restricted for those genes which are active during the embryonic state but repressed during differentiation. After generalizing a large variety of different types of carcinogenic agents and their action, which in principle are capable of activating embryonic genes, a preliminary notion of the carcinogenic process was derived. It appears that the bioalkylation pattern can be perturbed by a variety of agents from electromagnetic radiation to ethionine. Specific genes or their corresponding repressors such as an embryonic type phospho-protein kinase would become derepressed because of their methylation status (or by some other analogous alteration, e.g., via a specific mutation of a proto-oncogene that would create an embryonic type kinase, DNA intercalation by planar molecules, or, a hereditary process such as V-type position effect). This would cause competent stem type precursor cells containing easily derepressed or partially repressed arrays of embryonic genes to become activated, producing many features characteristic of a neoplastic cell.
本文讨论了胚胎基因这一术语，并给出了一个操作性定义，即它仅限于那些在胚胎状态下活跃但在分化过程中受到抑制的基因。在概括了多种不同类型的致癌剂及其作用（原则上能够激活胚胎基因）之后，得出了致癌过程的初步概念。似乎生物烷基化模式会受到从电磁辐射到乙硫氨酸等多种因素的干扰。特定基因或其相应的阻遏物，如胚胎型磷酸蛋白激酶，会因其甲基化状态（或通过其他类似改变，例如原癌基因的特定突变产生胚胎型激酶、平面分子的DNA嵌入或遗传过程如V型位置效应）而解除抑制。这将导致含有易于解除抑制或部分抑制的胚胎基因阵列的有能力的干细胞型前体细胞被激活，产生许多肿瘤细胞特有的特征。
