夏科-马里-图斯病患者的妊娠与分娩

Pregnancies and deliveries in patients with Charcot-Marie-Tooth disease.

作者信息

Hoff Jana Midelfart, Gilhus Nils Erik, Daltveit Anne Kjersti

机构信息

Section for Neurology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.

出版信息

Neurology. 2005 Feb 8;64(3):459-62. doi: 10.1212/01.WNL.0000150933.65709.96.

DOI:10.1212/01.WNL.0000150933.65709.96

PMID:15699375

Abstract

OBJECTIVE

To investigate the effect of maternal Charcot-Marie-Tooth disease (CMT) on pregnancy and delivery.

METHODS

Data from the Medical Birth Registry of Norway 1967 to 2002 were surveyed. This registry has compulsory notification of all births. One hundred eight births by mothers with CMT were identified. The reference group consisted of all 2.1 million births by mothers without CMT.

RESULTS

Women with CMT had a higher occurrence of presentation anomalies (9.3 vs 4.5%; p = 0.04) and bleeding post partum (12.0 vs 5.8%; p = 0.02). The rate of operative delivery was twice that of the reference group (29.6 vs 15.3%; p = 0.002), and forceps was used three times as often in the CMT group (9.3 vs 2.7; p < 0.001). The majority of CMT cesarean sections were emergency sections.

CONCLUSION

Charcot-Marie-Tooth disease increases the risk for complications during delivery, which is linked to a higher occurrence of emergency interventions during birth.

摘要

目的

探讨母亲患夏科-马里-图斯病（CMT）对妊娠和分娩的影响。

方法

对挪威1967年至2002年医疗出生登记处的数据进行调查。该登记处对所有出生情况进行强制通报。共识别出108例CMT母亲的分娩情况。对照组由所有210万例非CMT母亲的分娩情况组成。

结果

CMT女性出现胎位异常的发生率更高（9.3%对4.5%；p = 0.04）以及产后出血发生率更高（12.0%对5.8%；p = 0.02）。手术分娩率是对照组的两倍（29.6%对15.3%；p = 0.002），且CMT组使用产钳的频率是对照组的三倍（9.3次对2.7次；p < 0.001）。大多数CMT剖宫产是急诊剖宫产。