Park Yongsoo, Kim Sinkyu, Park Sukyung, Kim Taewha, Yu Liping, Rewers Marian, Eisenbarth George S
Department of Internal Medicine, Hanyang University Hospital, 249-1 Kyomun-dong, Kuri, Kyunggi-do, 471-020, Korea.
Ann N Y Acad Sci. 2004 Dec;1037:69-73. doi: 10.1196/annals.1337.010.
Type 1 diabetes (T1D) is frequently associated with other autoimmune diseases. The occurrence of common features of autoimmune diseases and the coassociation of multiple autoimmune diseases in the same individual or family support the notion that there may be common genetic factors. We previously reported that immunogenetic markers of T1D were similar in Korean and U.S. families. We hypothesized that nonislet autoimmunity might be expressed in a similar manner in Korean as well as in Caucasian patients and correlated with the DRB1-DQB1 haplotypes. Twenty-five percent of Korean patients with T1D (32/128) had antithyroid autoantibodies (ATA+), whereas eight percent of age-matched controls were ATA+ [OR = 3.7 (95% CI:1.0-12.0), P < 0.05]. Twenty-three percent (84/369) of age-matched T1D patients from the U.S. had ATA (not statistically different from that in Koreans). None of the Korean patients nor the family members were positive for 21-hydroxylase (21OH) or transglutaminase autoantibodies (TG). In contrast, in U.S. patients, nine T1D patients (2.4%) were 21OH+ (not statistically different from that in Koreans) and 39 T1D patients (10.6%) were TG+ [OR = 30.7 (95% CI: 4.6-111), P < 10(-4) vs. Korean patients]. Nonislet autoimmunity is prevalent in Korean and U.S. patients with T1D and their family members, but specific forms of autoimmunity differ even after matching for their HLA haplotypes. Individuals with T1D and their relatives frequently develop a panel of autoantibodies, perhaps due to other common susceptibility genes that are shared among first-degree relatives.
1型糖尿病（T1D）常与其他自身免疫性疾病相关。自身免疫性疾病共同特征的出现以及多种自身免疫性疾病在同一个体或家族中的共同发生支持了可能存在共同遗传因素的观点。我们之前报道过，韩国和美国家族中T1D的免疫遗传标记相似。我们假设，非胰岛自身免疫在韩国患者和白种人患者中可能以相似的方式表现，并与DRB1 - DQB1单倍型相关。25%的韩国T1D患者（32/128）有抗甲状腺自身抗体（ATA阳性），而年龄匹配的对照组中有8%为ATA阳性[比值比（OR）= 3.7（95%可信区间：1.0 - 12.0），P < 0.05]。来自美国的年龄匹配的T1D患者中有23%（84/369）有ATA（与韩国患者无统计学差异）。韩国患者及其家庭成员中均无21 - 羟化酶（21OH）或转谷氨酰胺酶自身抗体（TG）阳性。相比之下，在美国患者中，9名T1D患者（2.4%）为21OH阳性（与韩国患者无统计学差异），39名T1D患者（10.6%）为TG阳性[与韩国患者相比，OR = 30.7（95%可信区间：4.6 - 111），P < 10⁻⁴]。非胰岛自身免疫在韩国和美国的T1D患者及其家庭成员中普遍存在，但即使在匹配了HLA单倍型后，自身免疫的具体形式仍有所不同。T1D患者及其亲属经常会出现一组自身抗体，这可能是由于一级亲属中共享的其他常见易感基因所致。
