精神药物诱发的尖端扭转型室速及其危险因素的患病率。
Torsade de pointes induced by psychotropic drugs and the prevalence of its risk factors.
作者信息
Justo D, Prokhorov V, Heller K, Zeltser D
机构信息
Department of Internal Medicine D, Tel-Aviv Sourasku Medical Center, Tel-Aviv, Israel.
出版信息
Acta Psychiatr Scand. 2005 Mar;111(3):171-6. doi: 10.1111/j.1600-0447.2004.00469.x.
OBJECTIVE
To investigate all published case reports of torsade de pointes (TdP) induced by psychotropic drugs (PDs) in order to examine the prevalence of risk factors for TdP prior to the drug initiation.
METHOD
We found 45 reports on 70 patients with TdP induced by PDs. Each report was analyzed for the presence of risk factors for TdP: female gender, heart disease, hypokalemia, high doses of offending agent, concomitant use of a QT interval prolonging agent, and a history of long-QT syndrome.
RESULTS
Female gender was the most common risk factor for TdP (71.4%). The other studied risk factors were also frequently present (34.2-14.2%). Nearly all patients had at least one and 51 (73%) patients had >2 risk factors for TdP prior to PD initiation.
CONCLUSION
We wish to raise the level of awareness of risk factors for TdP in the psychiatric community.
目的
调查所有已发表的由精神药物（PDs）诱发尖端扭转型室速（TdP）的病例报告，以检查在开始使用药物之前TdP危险因素的患病率。
方法
我们找到了45篇关于70例由PDs诱发TdP患者的报告。对每篇报告分析是否存在TdP的危险因素：女性、心脏病、低钾血症、高剂量致病药物、同时使用延长QT间期的药物以及长QT综合征病史。
结果
女性是TdP最常见的危险因素（71.4%）。其他研究的危险因素也经常出现（34.2 - 14.2%）。几乎所有患者在开始使用PDs之前至少有一个TdP危险因素，51例（73%）患者有超过2个TdP危险因素。
结论
我们希望提高精神科领域对TdP危险因素的认识水平。
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