Zachariae C, Johansen J D, Rastogi S C, Menné T
Department of Dermatology, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
Contact Dermatitis. 2005 Jan;52(1):6-8. doi: 10.1111/j.0105-1873.2005.00478.x.
Of the 766 patients with eczematous skin disease patch tested in 2003 at the Department of Dermatology, University Clinic Gentofte, 38 (4.9%) showed a positive reaction to methyldibromo glutaronitrile (MDBGN), and in an additional 2 patients, a doubtful positive patch test reaction was found to be of relevance. Among these, 27 had hand eczema, with a relevant exposure predominantly from wash-off products, either liquid soaps or shampoos, in 24 patients. Following identification of the allergen by patch testing and subsequent avoidance of products containing MDBGN, the hand eczema either improved or cleared in 19 patients. Chemical analysis showed 11 p.p.m. to 473 p.p.m. MDBGN in products used by the patients. Based on the present clinical study and accumulated evidence in the literature, it is concluded that MDBGN is not suitable for use in any type of cosmetic product.
2003年在根措夫特大学临床医院皮肤科接受斑贴试验的766例湿疹性皮肤病患者中，38例（4.9%）对甲基二溴戊二腈（MDBGN）呈阳性反应，另有2例患者斑贴试验反应可疑阳性且与病情相关。其中，27例患有手部湿疹，24例患者主要因冲洗型产品（液体肥皂或洗发水）接触到相关过敏原。通过斑贴试验确定过敏原并随后避免使用含MDBGN的产品后，19例患者的手部湿疹有所改善或痊愈。化学分析显示患者使用的产品中MDBGN含量为百万分之11至百万分之473。基于目前的临床研究和文献中积累的证据，得出结论：MDBGN不适用于任何类型的化妆品。
