Gruvberger B, Andersen K E, Brandão F M, Bruynzeel D P, Bruze M, Frosch P J, Goossens A, Lahti A, Lindberg M, Menné T, Orton D, Seidenari S
Department of Occupational and Environmental Dermatology, Malmö University Hospital, S-205 02 Malmö, Sweden.
Contact Dermatitis. 2005 Jan;52(1):14-8. doi: 10.1111/j.0105-1873.2005.00480.x.
Contact allergy to and allergic contact dermatitis from methyldibromo glutaronitrile (MDBGN) have frequently been reported. As there has been no agreement on which MDBGN test preparation to use, a study was initiated to help determine the optimal patch test preparation for MDBGN. 2661 consecutively patch tested patients at 11 test clinics representing 9 European countries participated. Petrolatum preparations with MDBGN at 1.0%, 0.5%, 0.3% and 0.1% were inserted in the standard series. Contact allergy rates were noted in the range 4.4-1.1% following decreasing test concentrations. Reactions not fulfilling all criteria to be classified as allergic reactions could represent either weak allergic or irritant reactions, and such reactions were noted in the range 8.2-0.5% with decreasing concentrations. A significant number of these reactions represented weak allergic reactions, as allergic reactions were obtained to higher patch test concentrations in the same individual. Morphologically irritant reactions were noted only for the highest test concentrations. In summary, the contact allergy rates and frequencies of doubtful and irritant reactions vary with the patch test concentration. The final decision on patch test concentration for MDBGN should not only rely on these factors but also include information on patch test concentrations required to diagnose individual cases with allergic contact dermatitis from MDBGN as well as results of repeated open application tests.
甲基二溴戊二腈（MDBGN）引起的接触性过敏和过敏性接触性皮炎屡有报道。由于对于使用哪种MDBGN测试制剂尚无定论，因此开展了一项研究以帮助确定MDBGN的最佳斑贴试验制剂。来自9个欧洲国家的11个测试诊所的2661名连续接受斑贴试验的患者参与了研究。将含1.0%、0.5%、0.3%和0.1% MDBGN的凡士林制剂纳入标准系列。随着测试浓度降低，接触过敏率在4.4% - 1.1%范围内。不符合全部过敏反应标准的反应可能代表弱阳性或刺激性反应，随着浓度降低，此类反应在8.2% - 0.5%范围内被观察到。这些反应中有相当一部分代表弱阳性反应，因为同一个体在更高的斑贴试验浓度下出现了过敏反应。仅在最高测试浓度下观察到形态学上的刺激性反应。总之，接触过敏率以及可疑和刺激性反应的频率随斑贴试验浓度而变化。MDBGN斑贴试验浓度的最终决定不应仅依赖于这些因素，还应包括诊断MDBGN过敏性接触性皮炎个体病例所需的斑贴试验浓度信息以及重复开放应用试验的结果。
