Pociello Almiñana N, Vilar Escrigas P, Luaces Cubells C
Sección de Urgencias, Servicio de Pediatría, Hospital Sant Joan de Deu-Corporacio Clinic, Universidad de Barcelona, Spain.
An Pediatr (Barc). 2005 Feb;62(2):171-3. doi: 10.1157/13071317.
Drug-induced esophagitis has frequently been reported in adults, with more than 100 substances involved. However, only a few cases occurring in the pediatric population have been published. The most frequently involved drugs are antibiotics and the incidence of esophagitis is thought to be greater than estimated due to the increase in antibiotic prescription in the last few decades. A medical history suggestive of retrosternal pain, odynophagia with or without dysphagia, and recent drug intake are suspicious for this entity. Although most cases are self-limiting, complications such as hemorrhage or perforation have been described. We present two cases of doxycycline-induced esophagitis in two teenagers that illustrate the clinical course, endoscopic pattern and treatment of this entity.
药物性食管炎在成人中常有报道，涉及100多种物质。然而，儿科人群中发生的此类病例仅有少数被发表。最常涉及的药物是抗生素，由于过去几十年抗生素处方的增加，食管炎的发病率被认为高于估计值。有胸骨后疼痛、吞咽痛伴或不伴吞咽困难以及近期用药史的病史提示可能患有此病。虽然大多数病例是自限性的，但也有出血或穿孔等并发症的描述。我们报告两例青少年多西环素引起的食管炎病例，以说明该病的临床病程、内镜表现及治疗方法。
