Lin Rongyi, Shi Ng Lian, Wang Chi-Hwa
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore.
Biomaterials. 2005 Jul;26(21):4476-85. doi: 10.1016/j.biomaterials.2004.11.014.
Doxorubicin (DOX), also known as adriamycin, is an anthracycline drug commonly used in cancer chemotherapy. Unfortunately, its therapeutic potential has been restricted by its dose limited cardiotoxicity and the resistance developed by the tumor cells to the molecule after some time of treatment. One way to overcome these problems is to encapsulate the drug in poly (D, L-lactide-co-glycolide) (PLGA) microparticles. This paper investigates the release characteristics of DOX from polymeric carriers fabricated using the spray-drying technique. The encapsulation efficiency, size and morphology of the various polymeric devices were also determined. In order to improve the release characteristics, Pluronic P105 (PLU) and poly (L-Lactide) (PLLA) are individually used in combination with PLGA. Finally, a cytotoxicity test was performed using Glioma C6 cancer cells to investigate the cytotoxicity of DOX delivered from PLGA microparticles. It has been found that the cytotoxicity of DOX to Glioma C6 cancer cells is enhanced when DOX is delivered from PLGA polymeric carrier.
阿霉素（DOX），也被称为多柔比星，是一种常用于癌症化疗的蒽环类药物。不幸的是，其治疗潜力受到其剂量限制性心脏毒性以及肿瘤细胞在治疗一段时间后对该分子产生的耐药性的限制。克服这些问题的一种方法是将药物封装在聚（D，L-丙交酯-共-乙交酯）（PLGA）微粒中。本文研究了通过喷雾干燥技术制备的聚合物载体中阿霉素的释放特性。还测定了各种聚合物装置的包封效率、尺寸和形态。为了改善释放特性，将普朗尼克P105（PLU）和聚（L-丙交酯）（PLLA）分别与PLGA联合使用。最后，使用胶质瘤C6癌细胞进行细胞毒性试验，以研究从PLGA微粒递送的阿霉素的细胞毒性。已发现当阿霉素从PLGA聚合物载体递送时，其对胶质瘤C6癌细胞的细胞毒性增强。
