Manome Yoshinobu, Kobayashi Toshiaki, Mori Mariko, Suzuki Rie, Funamizu Naotake, Akiyama Nobutake, Inoue Sachiko, Tabata Yasuhiko, Watanabe Michiko
Department of Molecular Cell Biology, Institute of DNA Medicine, Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-ku, Tokyo 105-8461, Japan.
Anticancer Res. 2006 Sep-Oct;26(5A):3317-26.
Implantable, biocompatible and biodegradable devices bearing an anticancer drug can provide promising local therapy to patients with malignant disorders. With the aim of treating brain tumors, especially gliomas, a membranous sheet containing doxorubicin was produced by co-polymerization to poly(D,L-lactide-co-glycolide) (PLGA). When release of the drug from the sheet was measured, sustained release continued until day 34. The data contrasted with the burst release from material containing a higher proportion of the drug. In terms of biodegradability, a subcutaneous 3 x 3-mm tetragonal sheet was almost completely absorbed by day 80. When a glioma was implanted subcutaneously and the tumor nodule exposed to the sheet, the device inhibited tumor growth significantly. The sheet consisted of an amorphous structure with cavities estimated to have a diameter of 0.5 - 3 microm by electron microscopic observation. Since the sheet is implantable, biodegradable and has a sustained-drug release property, the device may play a role in the local therapy of brain tumors.
携带抗癌药物的可植入、生物相容且可生物降解的装置可为患有恶性疾病的患者提供有前景的局部治疗。为了治疗脑肿瘤，尤其是神经胶质瘤，通过与聚（D，L-丙交酯-共-乙交酯）（PLGA）共聚制备了一种含阿霉素的膜片。当测量药物从膜片中的释放情况时，持续释放一直持续到第34天。该数据与来自含较高比例药物的材料的突释形成对比。就生物降解性而言，一个皮下3×3毫米的四边形片在第80天时几乎被完全吸收。当将神经胶质瘤皮下植入并使肿瘤结节暴露于该片时，该装置显著抑制了肿瘤生长。通过电子显微镜观察，该片由具有估计直径为0.5 - 3微米的腔的无定形结构组成。由于该片可植入、可生物降解且具有药物缓释特性，该装置可能在脑肿瘤局部治疗中发挥作用。
