沉默的恶性疟原虫变种启动子可通过内含子中沉默元件的自发缺失在体内被激活。
A silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron.
作者信息
Gannoun-Zaki Laïla, Jost Amy, Mu Jianbing, Deitsch Kirk W, Wellems Thomas E
机构信息
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8132, USA.
出版信息
Eukaryot Cell. 2005 Feb;4(2):490-2. doi: 10.1128/EC.4.2.490-492.2005.
Abstract
Introns of Plasmodium falciparum var genes act as transcriptional silencing elements that help control antigenic variations. In transfected episomes, intron silencing of a drug-selectable marker under var promoter control is reversed by the spontaneous deletion of key intron regions. The resulting promoter activation does not affect the transcription of chromosomal var genes.
摘要
恶性疟原虫var基因的内含子作为转录沉默元件，有助于控制抗原变异。在转染的附加体中，var启动子控制下药物选择标记的内含子沉默会因关键内含子区域的自发缺失而逆转。由此产生的启动子激活并不影响染色体var基因的转录。
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