端粒外转录及其调控。
Subtelomeric Transcription and its Regulation.
机构信息
Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, France.
ncRNA, Epigenetic and Genome Fluidity, CNRS UMR 3244, Sorbonne Université, PSL University, Institut Curie, Centre de Recherche, 26 rue d'Ulm, 75248, Paris, France.
出版信息
J Mol Biol. 2020 Jul 10;432(15):4199-4219. doi: 10.1016/j.jmb.2020.01.026. Epub 2020 Feb 6.
The subtelomeres, highly heterogeneous repeated sequences neighboring telomeres, are transcribed into coding and noncoding RNAs in a variety of organisms. Telomereproximal subtelomeric regions produce non-coding transcripts i.e., ARRET, αARRET, subTERRA, and TERRA, which function in telomere maintenance. The role and molecular mechanisms of the majority of subtelomeric transcripts remain unknown. This review depicts the current knowledge and puts into perspective the results obtained in different models from yeasts to humans.
端粒附近的亚端粒区产生非编码转录本，如 ARRET、αARRET、subTERRA 和 TERRA，它们在端粒维持中发挥作用。大多数亚端粒转录本的作用和分子机制仍不清楚。本文描述了目前的知识，并从酵母到人类的不同模型中获得的结果进行了分析。
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