Charles Andrew
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA.
Sci STKE. 2005 Feb 8;2005(270):pe6. doi: 10.1126/stke.2702005pe6.
Neuronal activity can stimulate an increase in astrocyte intracellular calcium concentration, which is propagated through neighboring astrocytes as a "calcium wave"; these calcium waves are accompanied by the release of glutamate. Sodium-dependent glutamate uptake leads to a secondary astrocytic sodium wave, accompanied by a wave of increased glucose uptake and metabolism. This metabolic wave may enable astrocytes to provide lactate as an energy source to neighboring active neurons and perhaps to distant neurons as well. Thus, one function of long-range intercellular calcium signaling in astrocytes may be to spatially coordinate their function in supporting neuronal metabolism.
神经元活动可刺激星形胶质细胞内钙浓度升高，这种升高作为“钙波”在相邻星形胶质细胞间传播；这些钙波伴随着谷氨酸的释放。钠依赖性谷氨酸摄取导致星形胶质细胞继发钠波，同时伴有葡萄糖摄取和代谢增加的波。这种代谢波可能使星形胶质细胞能够为相邻的活跃神经元以及可能也为远处的神经元提供乳酸作为能量来源。因此，星形胶质细胞中长距离细胞间钙信号传导的一个功能可能是在空间上协调它们在支持神经元代谢方面的功能。
