Walters Julian R F
Gastroenterology Section, Department of Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Curr Opin Gastroenterol. 2004 Mar;20(2):70-6. doi: 10.1097/00001574-200403000-00004.
This paper will discuss recent research that has provided new insights into the molecular and cell biology of the small intestine.
Differentiation of the epithelial cell lineages, including the enterocytes, enteroendocrine, Goblet and Paneth cells, from the stem cells is better understood. Important interactions have been demonstrated between these cells, luminal bacteria, and underlying mesenchymal tissue. Intestine-specific gene expression is regulated by transcription factors that are becoming well characterized, including CDX1, CDX2 and HNF1. The actions of growth factors such as GLP-2 and EGF are now known to be complex, demonstrating multiple effects in this tissue at a number of levels.
Progress in the cellular and molecular biology of the small intestine is producing many intriguing new findings.
本文将讨论近期的研究，这些研究为小肠的分子和细胞生物学提供了新的见解。
现在对包括肠上皮细胞、肠内分泌细胞、杯状细胞和潘氏细胞在内的上皮细胞谱系从干细胞的分化有了更好的理解。已经证明了这些细胞、腔内细菌和下层间充质组织之间的重要相互作用。肠道特异性基因表达受转录因子调控，这些转录因子正得到很好的表征，包括CDX1、CDX2和HNF1。现在已知生长因子如GLP-2和EGF的作用很复杂，在多个水平上对该组织表现出多种效应。
小肠细胞和分子生物学的进展正在产生许多有趣的新发现。
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