Janak P H, Keppel G, Martinez J L
Department of Psychology, University of California, Berkeley 94720.
Psychopharmacology (Berl). 1992;106(3):383-7. doi: 10.1007/BF02245422.
The effects of post-training cocaine administration were tested on retention of a one-way active avoidance task in rats. A 5.0 mg/kg IP dose of cocaine enhanced retention of the avoidance task, in three separate experiments, as indicated by an increase in the number of avoidances made when animals were tested 24 h after training, while both a lower (2.5 mg/kg) and a higher (7.5 mg/kg) cocaine dose had no effect. Lidocaine (4-8 mg/kg) administered post-training did not reliably affect retention in the same task. Cocaine's ability to enhance retention depended on the interval between training and drug injection such that only cocaine administered directly after training enhanced retention the following day. The results show that post-training cocaine administration enhances retention of an active avoidance task in rats, and that this effect is probably independent of the anesthetic properties of the drug.
研究了训练后给予可卡因对大鼠单向主动回避任务记忆保持的影响。在三项独立实验中，5.0毫克/千克腹腔注射剂量的可卡因增强了回避任务的记忆保持，这表现为动物在训练后24小时接受测试时回避次数增加，而较低剂量（2.5毫克/千克）和较高剂量（7.5毫克/千克）的可卡因均无此作用。训练后给予利多卡因（4 - 8毫克/千克）对同一任务的记忆保持没有可靠影响。可卡因增强记忆保持的能力取决于训练与药物注射之间的间隔时间，即只有在训练后直接给予可卡因才能增强次日的记忆保持。结果表明，训练后给予可卡因可增强大鼠主动回避任务的记忆保持，且这种作用可能与药物的麻醉特性无关。
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