Rodriguez W A, Rodriguez S B, Phillips M Y, Martinez J L
Department of Psychology, University of California, Berkeley 94720.
Behav Brain Res. 1993 Dec 31;59(1-2):125-9. doi: 10.1016/0166-4328(93)90158-m.
We previously demonstrated that cocaine administered immediately prior to a reactivation episode comprised of re-exposure to selected features of the original fear-conditioning session alters subsequent memory retrieval or reconsolidation. In the present study we determined that, similar to pre-reactivation administration, post-reactivation administration of cocaine also alters memory retrieval or reorganization, as measured by subsequent conditioned performance. The dose-response function for this effect of cocaine was U-shaped; maximal enhancement of subsequent avoidance performance was produced by a 7.5 mg/kg i.p. dose of cocaine. Because a dose of lidocaine equimolar to the effective cocaine dose was found not to alter subsequent conditioned performance, the effect of cocaine on memory processing most likely is not attributable to its local anesthetic properties.
我们之前证明，在由重新暴露于原始恐惧条件训练环节的特定特征所构成的再激活事件之前立即给予可卡因，会改变随后的记忆提取或再巩固。在本研究中，我们确定，与再激活前给药类似，可卡因再激活后给药也会改变记忆提取或重组，这通过随后的条件化表现来衡量。可卡因这种作用的剂量反应函数呈U形；腹腔注射7.5mg/kg剂量的可卡因可使随后的回避表现得到最大程度增强。由于发现等摩尔于有效可卡因剂量的利多卡因剂量不会改变随后的条件化表现，可卡因对记忆加工的作用很可能不归因于其局部麻醉特性。
