Introini-Collison I B, McGaugh J L
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.
Psychopharmacology (Berl). 1989;99(4):537-41. doi: 10.1007/BF00589905.
Mice were trained on a one-trial inhibitory avoidance task and given immediate post-training intraperitoneal injections of cocaine (0.03-1.00 mg/kg). On a retention test 24 h later, the retention latencies of mice given the 0.10 mg/kg dose were significantly higher than those of the controls. The effect of cocaine on retention was time-dependent: retention latencies were not altered in animals given cocaine 60 min after training. Administration of cocaine (0.1 mg/kg) prior to the retention test did not modify the retention performance of mice that received either saline or cocaine (0.1 mg/kg) immediately post-training. The findings suggest that cocaine affects retention by influencing post-training processes involved in memory storage.
小鼠接受单次试验性抑制性回避任务训练，并在训练后立即腹腔注射可卡因（0.03 - 1.00毫克/千克）。在24小时后的记忆保持测试中，给予0.10毫克/千克剂量可卡因的小鼠的记忆保持潜伏期显著高于对照组。可卡因对记忆保持的影响具有时间依赖性：训练后60分钟给予可卡因的动物的记忆保持潜伏期没有改变。在记忆保持测试前给予可卡因（0.1毫克/千克）并没有改变训练后立即接受生理盐水或可卡因（0.1毫克/千克）的小鼠的记忆保持表现。这些发现表明，可卡因通过影响训练后参与记忆存储的过程来影响记忆保持。
