Ceylan S, Ilbay K, Baykal S, Ceylan S, Sener U, Ozmenoğlu M, Kalelioğlu M, Aktürk F, Komsuoğlu S S, Ozoran A
Department of Neurosurgery, KTU Medical Faculty, Trabzon, Turkey.
Res Exp Med (Berl). 1992;192(1):23-33. doi: 10.1007/BF02576254.
The effects of nimodipine and thyrotropin-releasing hormone (TRH) were compared in a clip-compression model of experimental spinal cord injuries (SCI) in rats. Thirty rats received a 50-g clip-compression injury on the cord at T9. Ten rats were given 0.02 mg/kg nimodipine and dextran 40 (3 ml) i.v. 1 h after injury. Ten rats were given 2 mg/kg TRH and dextran 40 (3 ml) i.v. 1 h after injury followed by 1 mg/kg per hour for 4 h. The remaining ten rats were given only saline. TRH treatment significantly improved somatosensory-evoked potentials (SEPs) and mean arterial blood pressures (MABPs), whereas nimodipine treatment had no effect on these variables (Fisher's exact test (P less than 0.01).
在大鼠实验性脊髓损伤（SCI）的夹闭压迫模型中，对尼莫地平和促甲状腺激素释放激素（TRH）的作用进行了比较。30只大鼠在T9水平接受50克夹闭压迫脊髓损伤。10只大鼠在损伤后1小时静脉注射0.02毫克/千克尼莫地平和右旋糖酐40（3毫升）。10只大鼠在损伤后1小时静脉注射2毫克/千克TRH和右旋糖酐40（3毫升），随后每小时注射1毫克/千克，共4小时。其余10只大鼠仅给予生理盐水。TRH治疗显著改善了体感诱发电位（SEPs）和平均动脉血压（MABPs），而尼莫地平治疗对这些变量没有影响（Fisher精确检验（P小于0.01））。
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