受体酪氨酸激酶躯干信号传导的功能与机制：来自果蝇胚胎末端发育的启示
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.
作者信息
Li Willis X
机构信息
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA.
出版信息
Dev Dyn. 2005 Mar;232(3):656-72. doi: 10.1002/dvdy.20295.
Abstract
The Torso receptor tyrosine kinase (RTK) is required for cell fate specification in the terminal regions (head and tail) of the early Drosophila embryo. Torso contains a split tyrosine kinase domain and belongs to the type III subgroup of the RTK superfamily that also includes the platelet-derived growth factor receptors, stem cell or steel factor receptor c-Kit proto-oncoprotein, colony-stimulating factor-1 receptor, and vascular endothelial growth factor receptor. The Torso pathway has been a model system for studying RTK signal transduction. Genetic and biochemical studies of Torso signaling have provided valuable insights into the biological functions and mechanisms of RTK signaling during early Drosophila embryogenesis.
摘要
躯干受体酪氨酸激酶（RTK）在早期果蝇胚胎的末端区域（头部和尾部）的细胞命运决定中是必需的。躯干含有一个分裂的酪氨酸激酶结构域，属于RTK超家族的III型亚组，该亚组还包括血小板衍生生长因子受体、干细胞或钢因子受体c-Kit原癌蛋白、集落刺激因子-1受体和血管内皮生长因子受体。躯干信号通路一直是研究RTK信号转导的模型系统。对躯干信号传导的遗传学和生物化学研究为果蝇早期胚胎发育过程中RTK信号传导的生物学功能和机制提供了有价值的见解。
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