匈牙利慢性丙型肝炎患者中庚型肝炎病毒和TT病毒的合并感染

Co-infections with hepatitis G and TT virus in patients with chronic hepatitis C in Hungary.

作者信息

Pár A, Takács Mária, Brojnás Judit, Berencsi Gy, Paál Mária, Horányi Margit, Miseta A, Hegedüs G, Mózsik Gy, Hunyady B

机构信息

First Department of Medicine, Medical Faculty, University of Pécs, Ifjúság ut 13, H-7624 Pécs, Hungary.

出版信息

Acta Microbiol Immunol Hung. 2004;51(4):437-47. doi: 10.1556/AMicr.51.2004.4.4.

DOI:10.1556/AMicr.51.2004.4.4

PMID:15704332

Abstract

The significance of co-infections with novel hepatitis viruses Hepatitis G (GBV-C, HGV) and TT virus (TTV) in chronic hepatitis C is not clear. We determined the prevalence of HGV RNA and TTV DNA in chronic hepatitis C patients and in asymptomatic hepatitis C virus (HCV) carriers, and assessed the influence of these agents on the course of HCV infection. Seventy-seven patients with chronic hepatitis C--50 of them treated with interferon (IFN)--and 33 HCV carriers with normal alanine aminotransferase have been investigated. Previous HBV infection was detected by testing serum HBsAg and aHBc. HGV RNA and TTV DNA were detected by PCR. In the healthy population, the prevalence of anti-HCV was 0.3%, HGV RNA 8.0% and TTV DNA 18.5%. In chronic hepatitis C HGV RNA occurred in 9.09% and TTV DNA in 40.25% of cases. In IFN-treated patients with sustained remission, the frequency of TTV was 20% vs. 45.7% found in non-responders. Among asymptomatic HCV-carriers, the prevalence of HGV RNA was 9.09% and TTV DNA 75.7%. Neither HGV RNA nor TTV DNA had apparent effect on the HCV infection. TTV was detected with the lowest frequency in persons with sustained remission due to IFN, suggesting antiviral effect of IFN on TTV.

摘要

新型肝炎病毒庚型肝炎病毒（GBV-C，HGV）和TT病毒（TTV）合并感染在慢性丙型肝炎中的意义尚不清楚。我们测定了慢性丙型肝炎患者和无症状丙型肝炎病毒（HCV）携带者中HGV RNA和TTV DNA的流行率，并评估了这些病原体对HCV感染病程的影响。我们对77例慢性丙型肝炎患者（其中50例接受干扰素治疗）和33例丙氨酸转氨酶正常的HCV携带者进行了研究。通过检测血清HBsAg和抗-HBc来检测既往HBV感染情况。通过PCR检测HGV RNA和TTV DNA。在健康人群中，抗-HCV的流行率为0.3%，HGV RNA为8.0%，TTV DNA为18.5%。在慢性丙型肝炎患者中，HGV RNA的出现率为9.09%，TTV DNA的出现率为40.25%。在接受干扰素治疗且获得持续缓解的患者中，TTV的检出率为20%，而在无反应者中为45.7%。在无症状HCV携带者中，HGV RNA的流行率为9.09%，TTV DNA为75.7%。HGV RNA和TTV DNA对HCV感染均无明显影响。在因干扰素治疗而获得持续缓解的患者中，TTV的检出频率最低，提示干扰素对TTV有抗病毒作用。