Pár Alajos, Takács Mária, Brojnás Judit, Berencsi György, Paál Mária, Horányi Margit, Miseta Attila, Hegedüs Géza, Mózsik Gyula, Hunyady Béla
Pécsi Tudományegyetem, Altalános Orvostudományi Kar, I. Belgyógyászati Klinika, Pécs.
Orv Hetil. 2004 May 9;145(19):987-92.
BACKGROUND/AIMS: The prevalence of co-infections with hepatitis B virus (HBV) and novel hepatitis viruses GBV-C (Hepatitis G virus, HGV) and TT virus (TTV) in chronic hepatitis C (HCV) infection has been studied. In patients with chronic hepatitis C and in asymptomatic healthy HCV carriers, the influence of these agents on the course of HCV infection was assessed.
a total of 110 HCV-positive individuals, among them 77 patients with chronic hepatitis C--50 of them treated with interferon (IFN)--and 33 HCV carriers with normal alanine aminotransferase have been investigated. HBV-DNA, HGV RNA and TTV DNA were detected by PCR, to determine HBsAg and anti-HBc ELISA technic has been used.
In the healthy population, the prevalence of anti-HCV was 0.3%, HBsAg 0.09%, anti-HBc 2.5%, HGV RNA 8.0% and TTV DNA 18.5%, respectively. In chronic hepatitis C HBsAg (accompanied with HBV-DNA) occurred in 1.29%, anti-HBc 25.97%, HGV RNA in 9.09% and TTV DNA in 40.25% of cases. In IFN-treated patients with sustained remission, the frequency of TTV was 20% vs. 45.7% found in non-responders. Among asymptomatic HCV-carriers, the prevalence of anti-HBc was 27.27%, HGV RNA 9.09% and TTV DNA 75.7% respectively.
Neither previous HBV infection, nor HGV RNA and TTV DNA had apparent effect on the course of chronic HCV infection. TTV was detected with the lowest frequency in persons with sustained remission due to IFN, suggesting antiviral effect of IFN on TTV.
背景/目的：对慢性丙型肝炎（HCV）感染合并乙型肝炎病毒（HBV）以及新型肝炎病毒GBV-C（庚型肝炎病毒，HGV）和TT病毒（TTV）感染的患病率进行了研究。评估了这些病原体对慢性丙型肝炎患者以及无症状健康HCV携带者的HCV感染病程的影响。
共对110例HCV阳性个体进行了研究，其中77例慢性丙型肝炎患者——其中50例接受了干扰素（IFN）治疗——以及33例丙氨酸氨基转移酶正常的HCV携带者。通过PCR检测HBV-DNA、HGV RNA和TTV DNA，采用ELISA技术检测HBsAg和抗-HBc。
在健康人群中，抗-HCV患病率分别为0.3%，HBsAg为0.09%，抗-HBc为2.5%，HGV RNA为8.0%，TTV DNA为18.5%。在慢性丙型肝炎中，HBsAg（伴有HBV-DNA）发生率为1.29%，抗-HBc为25.97%，HGV RNA为9.09%，TTV DNA为40.25%。在接受IFN治疗且持续缓解的患者中，TTV出现频率为20%，而在无反应者中为45.7%。在无症状HCV携带者中，抗-HBc患病率分别为27.27%，HGV RNA为9.09%，TTV DNA为75.7%。
既往HBV感染、HGV RNA和TTV DNA对慢性HCV感染病程均无明显影响。在因IFN治疗而持续缓解的患者中TTV检出频率最低，提示IFN对TTV有抗病毒作用。
