Falcini F, Pignone A, Matucci-Cerinic M, Camiciottoli G, Taccetti G, Trapani S, Zammarchi E, Lombardi A, Bartolozzi G, Cagnoni M
Department of Paediatrics, University of Florence, Italy.
Scand J Rheumatol. 1992;21(2):82-4. doi: 10.3109/03009749209095073.
Lung involvement in children affected with Systemic Sclerosis (SSc) has been studied. We used ventilation and perfusion scans and compared the results to those obtained with traditional pulmonary function tests. The vascular pulmonary area was examined with a gama-camera after infusion of 99mTc microspheres, while the alveolo-capillary membrane and the airways were investigated after administration of a radioaerosol, (99mTc DTPA). Pulmonary function tests revealed either alteration of the airways or a considerable involvement of the alveolo-capillary membrane in two patients. On the other hand ventilation scan showed airways alterations and a severe decrease of the alveolocapillary permeability in all patients. Our study indicates that ventilation scans may be useful in the diagnosis of early modifications of the lung function also in paediatric age and may complement the data obtained from traditional function tests.
对患有系统性硬化症（SSc）的儿童的肺部受累情况进行了研究。我们使用了通气和灌注扫描，并将结果与传统肺功能测试所得结果进行比较。在注入99mTc微球后，用γ相机检查肺血管区域，而在给予放射性气溶胶（99mTc DTPA）后，对肺泡-毛细血管膜和气道进行研究。肺功能测试显示，两名患者出现气道改变或肺泡-毛细血管膜明显受累。另一方面，通气扫描显示所有患者均有气道改变以及肺泡-毛细血管通透性严重下降。我们的研究表明，通气扫描在诊断儿童早期肺功能改变方面可能有用，并且可以补充从传统功能测试获得的数据。
