Pignone A, Matucci-Cerinic M, Lombardi A, Fedi R, Fargnoli R, De Dominicis R, Cagnoni M
Institute of Medical Clinic IV, University of Florence, Italy.
Clin Rheumatol. 1992 Dec;11(4):465-72. doi: 10.1007/BF02283100.
The real utility of high resolution computed tomography (HRCT) for early detection of lung involvement was investigated in eighteen patients affected with systemic sclerosis (SSc). The results obtained from HRCT have been compared with traditional (chest radiographs, pulmonary function tests (PFT)) and nontraditional (ventilation and perfusion scintiscan) modalities of lung investigation. A significant statistical correlation (p < 0.001) between HRCT scans and chest radiographs was observed. Moreover, HRCT was more sensitive in the detection of early pulmonary interstitial involvement and more accurate in the assessment of interstitial fibrosis in cases with severe lung involvement. A statistical correlation (P < 0.001) between HRCT and the modalities of investigation of alveolo-capillary membrane--as PFT and ventilation scintiscan--was also observed. These results indicate that in SSc HRCT may be a useful technique for assessing early pulmonary involvement and for complementing other methodologies of investigation of lung function.
对18例系统性硬化症（SSc）患者进行了高分辨率计算机断层扫描（HRCT）用于早期检测肺部受累情况的实际效用研究。将HRCT获得的结果与传统（胸部X光片、肺功能测试（PFT））和非传统（通气和灌注闪烁扫描）肺部检查方式进行了比较。观察到HRCT扫描与胸部X光片之间存在显著的统计学相关性（p < 0.001）。此外，HRCT在检测早期肺间质受累方面更敏感，在评估严重肺部受累病例的间质纤维化方面更准确。还观察到HRCT与肺泡-毛细血管膜的检查方式（如PFT和通气闪烁扫描）之间存在统计学相关性（P < 0.001）。这些结果表明，在系统性硬化症中，HRCT可能是评估早期肺部受累情况以及补充其他肺功能检查方法的有用技术。
