人类与黑猩猩精细尺度重组率的比较。

Comparison of fine-scale recombination rates in humans and chimpanzees.

作者信息

Winckler Wendy, Myers Simon R, Richter Daniel J, Onofrio Robert C, McDonald Gavin J, Bontrop Ronald E, McVean Gilean A T, Gabriel Stacey B, Reich David, Donnelly Peter, Altshuler David

机构信息

Department of Molecular Biology and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114-2622, USA.

出版信息

Science. 2005 Apr 1;308(5718):107-11. doi: 10.1126/science.1105322. Epub 2005 Feb 10.

DOI:10.1126/science.1105322

PMID:15705809

Abstract

We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite approximately 99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.

摘要

我们通过分析人类和黑猩猩两个物种的多态性数据，比较了直系同源基因座上的精细尺度重组率。在这两个物种中均获得了强有力的统计学证据，证明存在重组热点。然而，尽管两个物种在DNA序列水平上有大约99%的一致性，但在两个物种中，重组热点很少（如果有的话）出现在相同位置，并且在精细尺度重组率的估计中未观察到相关性。因此，重组率的局部模式已经快速进化，其方式与DNA序列的变化不成比例。