Chhajed Prashant N, Kaegi Bruno, Rajasekaran Rajeevan, Tamm Michael
Division of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, CH-4031, Basel, Switzerland.
Chest. 2005 Feb;127(2):585-8. doi: 10.1378/chest.127.2.585.
Changes in Paco(2) have not been described during thoracoscopy under sedation-assisted local anesthesia. We hypothesized that hypoventilation might occur secondary to administration of sedatives and decreased ventilation in one lung.
Prospectively measure cutaneous carbon dioxide tension (Pcco(2)) in addition to pulse oximetric saturation (Spo(2)) using a new combined digital sensor to examine the occurrence of hypoventilation during thoracoscopy under sedation-assisted local anesthesia.
University hospital.
Following validation studies, Pcco(2) was prospectively measured in 16 consecutive patients undergoing thoracoscopy under sedation-assisted local anesthesia using a combined digital earlobe sensor measuring Spo(2) (percentage) and Pcco(2) (millimeters of mercury). All patients received supplemental oxygen. Routine BP monitoring and Spo(2) was continued. Patients received IV hydrocodone, 5 mg, and intermittent boluses or IV midazolam and pethidine.
Mean baseline Pcco(2) measurement was 39.1 +/- 7.2 mm Hg (+/- SD) [range, 27.5 to 50.5 mm Hg], and peak measurement during the procedure was 52.3 +/- 10.3 mm Hg (range, 37.2 to 77 mm Hg) [p < 0.001]. Median and mean changes in Pcco(2) measurement from baseline were 13.0 mm Hg and 13.2 +/- 5.3 mm Hg (range, 5.5 to 27.8 mm Hg), respectively. Mean fall in Spo(2) during the procedure was 4.6 +/- 3.2% (range, 1 to 14%).
Thoracoscopy performed under sedation-assisted local anesthesia is associated with significant hypoventilation. Combined measurement of Spo(2) and Pcco(2) during thoracoscopy is a novel approach in the monitoring of ventilation, enhancing patient safety, and might allow to guide the administration of sedation in a better way.
在镇静辅助局部麻醉下行胸腔镜检查期间,尚未见有关动脉血二氧化碳分压(Paco₂)变化的描述。我们推测,低通气可能继发于镇静剂的使用以及一侧肺通气量减少。
使用一种新型组合数字传感器,在前瞻性测量脉搏血氧饱和度(Spo₂)的同时测量皮肤二氧化碳分压(Pcco₂),以检查在镇静辅助局部麻醉下行胸腔镜检查期间低通气的发生情况。
大学医院。
在进行验证研究后,使用一种组合数字耳垂传感器对16例连续接受镇静辅助局部麻醉下胸腔镜检查的患者前瞻性测量Pcco₂,该传感器可测量Spo₂(百分比)和Pcco₂(毫米汞柱)。所有患者均接受补充氧气。持续进行常规血压监测和Spo₂监测。患者接受静脉注射5毫克氢可酮以及间歇性推注或静脉注射咪达唑仑和哌替啶。
Pcco₂测量的平均基线值为39.1±7.2毫米汞柱(±标准差)[范围为27.5至50.5毫米汞柱],术中测量的峰值为52.3±10.3毫米汞柱(范围为37.2至77毫米汞柱)[p<0.001]。Pcco₂测量值相对于基线的中位数和平均变化分别为13.0毫米汞柱和13.2±5.3毫米汞柱(范围为5.5至27.8毫米汞柱)。术中Spo₂的平均下降幅度为4.6±3.2%(范围为1至14%)。
在镇静辅助局部麻醉下行胸腔镜检查与明显的低通气有关。在胸腔镜检查期间联合测量Spo₂和Pcco₂是监测通气、提高患者安全性的一种新方法,并且可能有助于更好地指导镇静剂的使用。