Wang Long-hu, Wu Gou-lian, Cheng Yi-yu
Department of Chinese Medicine Sciences and Engineering, Zhejiang University, Hangzhou 310027, China.
Zhongguo Zhong Yao Za Zhi. 2004 Apr;29(4):289-92.
Recently, chitosan has been widely used as a clarifier in clarification procedure for many kinds of TCM, which is better than alcohol in retaining active substances, such as polysaccharids, as well as the removal of heavy metals. Because it is a biocompatible polymer with low toxicity and can be biodegradable in vivo, chitosan with its derivatives is one of the ideal materials for drug controlled release systems to enhance the efficacy and reliability of TCM drug therapy. On the other hand, chitosan, the only natural alkalic polysaccharid, also has several therapeutic effects such as anti-bacteria, antipyrotic and ulcer healing. Chitosan and its derivatives wide application prosperity in pharmaceutical industry of Chinese medicine.
近年来,壳聚糖作为澄清剂在多种中药澄清工艺中得到广泛应用,在保留多糖等活性成分以及去除重金属方面比乙醇效果更好。由于壳聚糖是一种生物相容性聚合物,毒性低且可在体内生物降解,壳聚糖及其衍生物是药物控释系统的理想材料之一,可提高中药药物治疗的疗效和可靠性。另一方面,壳聚糖作为唯一的天然碱性多糖,还具有抗菌、退热和促进溃疡愈合等多种治疗作用。壳聚糖及其衍生物在中药制药行业具有广阔的应用前景。