Doyle Frank, De La Harpe Davida, McGee Hannah, Shelley Emer, Conroy Ronán
Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, 123 St, Stephen's Green, Dublin 2, Ireland.
BMC Cardiovasc Disord. 2005 Feb 11;5(1):5. doi: 10.1186/1471-2261-5-5.
Shorter time to treatment is associated with lower mortality in acute coronary syndromes (ACS). A previous (1994) survey showed substantial delays for acute myocardial infarction (AMI) in Ireland. The present study compared current practice with 1994 and surveyed acute coronary syndromes as a more complete contemporary evaluation of critical cardiac care than assessing AMI alone.
Following ethics committee approval, all centres (N = 39) admitting acute cardiac patients to intensive/coronary care unit provided information on 1365 episodes. A cross-sectional survey design was employed.
Since 1994, median hospital arrival to thrombolysis time was reduced by 41% (76 to 45 minutes). Thrombolysis was delivered more often in the emergency department in 2003 (48% vs 2%). Thrombolysis when delivered in the emergency department was achieved faster than thrombolysis delivered in intensive/coronary care (35 mins v 60 mins; z = 5.62, p < .0001). Suspected AMI patients who did not subsequently receive thrombolysis took longer to present to hospital (5 h vs 2 h 34 mins; z = 7.33, p < .0001) and had longer transfer times to the intensive/coronary care unit following arrival (2 h 17 mins vs 1 h 10 mins; z = 8.92, p < .0001). Fewer confirmed AMI cases received thrombolysis in 2003 (43% vs 58%). There was an increase in confirmed cases of AMI from 1994 (70% to 87%).
Substantial improvements in time to thrombolysis have occurred since 1994, probably relating to treatment provision in emergency departments. Patient delay pre-hospital is still the principal impediment to effective treatment of ACS. A recent change of definition of AMI may have precluded an exact comparison between 1994 and 2003 data.
急性冠状动脉综合征(ACS)患者接受治疗的时间越短,死亡率越低。此前(1994年)的一项调查显示,爱尔兰急性心肌梗死(AMI)患者的治疗存在显著延迟。本研究将当前的治疗情况与1994年进行了比较,并对急性冠状动脉综合征进行了调查,作为对重症心脏护理更全面的当代评估,而不仅仅是评估急性心肌梗死。
经伦理委员会批准,所有收治急性心脏病患者至重症监护室/冠心病监护病房的中心(N = 39)提供了1365例病例的信息。采用横断面调查设计。
自1994年以来,从入院到溶栓的中位时间缩短了41%(从76分钟降至45分钟)。2003年,急诊科进行溶栓治疗的情况更为常见(48%对2%)。在急诊科进行溶栓治疗比在重症监护室/冠心病监护病房进行溶栓治疗更快(35分钟对60分钟;z = 5.62,p <.0001)。未接受溶栓治疗的疑似急性心肌梗死患者到医院就诊的时间更长(5小时对2小时34分钟;z = 7.33,p <.0001),到达后转至重症监护室/冠心病监护病房的时间也更长(2小时17分钟对1小时10分钟;z = 8.92,p <.0001)。2003年接受溶栓治疗的确诊急性心肌梗死病例减少(43%对58%)。确诊的急性心肌梗死病例自1994年以来有所增加(从70%增至87%)。
自1994年以来,溶栓时间有了显著改善,这可能与急诊科的治疗提供有关。院前患者延误仍是急性冠状动脉综合征有效治疗的主要障碍。急性心肌梗死定义的近期变化可能妨碍了对1994年和2003年数据进行准确比较。