The Brain Institute, University of Utah, 383 Colorow Drive, Salt Lake City, UT 84108, USA.
Bipolar Disord. 2012 Sep;14(6):607-17. doi: 10.1111/j.1399-5618.2012.01040.x. Epub 2012 Jul 20.
To compare the concentrations of high-energy phosphorus metabolites associated with mitochondrial function in the frontal lobe of depressed adolescents with bipolar disorder (BD) and healthy controls (HC).
We used in vivo phosphorus-31 magnetic resonance spectroscopy ((31) P-MRS) at 3 Tesla to measure phosphocreatine (PCr), beta-nucleoside triphosphate (β-NTP), inorganic phosphate (Pi), and other neurometabolites in the frontal lobe of eight unmedicated and six medicated adolescents with bipolar depression and 24 adolescent HCs.
Analysis of covariance, including age as a covariate, revealed differences in PCr (p=0.037), Pi (p=0.017), and PCr/Pi (p=0.002) between participant groups. Percentage neurochemical differences were calculated with respect to mean metabolite concentrations in the HC group. Post-hoc Tukey-Kramer analysis showed that unmedicated BD participants had decreased Pi compared with both HC (17%; p=0.038) and medicated BD (24%; p=0.022). The unmedicated BD group had increased PCr compared with medicated BD (11%; p=0.032). The PCr/Pi ratio was increased in unmedicated BD compared with HC (24%; p=0.013) and with medicated BD (39%; p=0.002). No differences in β-NTP or pH were observed.
Our results support the view that frontal lobe mitochondrial function is altered in adolescent BD and may have implications for the use of Pi as a biomarker. These findings join volumetric studies of the amygdala, and proton MRS studies of n-acetyl aspartate in pointing to potential differences in neurobiology between pediatric and adult BD.
比较伴有双相障碍（BD）的抑郁青少年与健康对照（HC）额叶中线粒体功能相关高能磷代谢物的浓度。
我们使用 3 特斯拉体内磷-31 磁共振波谱（31P-MRS）测量 8 名未经治疗和 6 名接受药物治疗的双相抑郁青少年及 24 名 HC 额叶中的磷酰肌酸（PCr）、β-核苷三磷酸（β-NTP）、无机磷（Pi）和其他神经代谢物。
协方差分析（包括年龄为协变量）显示参与者组之间在 PCr（p=0.037）、Pi（p=0.017）和 PCr/Pi（p=0.002）方面存在差异。相对于 HC 组平均代谢物浓度，计算了神经化学物质差异的百分比。事后 Tukey-Kramer 分析显示，未经治疗的 BD 患者的 Pi 水平与 HC（17%，p=0.038）和接受药物治疗的 BD（24%，p=0.022）相比均降低。未经治疗的 BD 组的 PCr 水平与接受药物治疗的 BD 组（11%，p=0.032）相比升高。与 HC（24%，p=0.013）和接受药物治疗的 BD（39%，p=0.002）相比，未经治疗的 BD 组的 PCr/Pi 比值升高。β-NTP 或 pH 无差异。
我们的结果支持这样的观点，即青少年 BD 额叶中线粒体功能发生改变，这可能对 Pi 作为生物标志物的使用具有意义。这些发现与杏仁核的容积研究以及 n-乙酰天冬氨酸的质子 MRS 研究一起，表明儿科和成人 BD 之间的神经生物学可能存在潜在差异。
